Knowhow offering
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| Title | Certolizumab Pegol |
| Knowhow is available for | Produce Certolizumab by fermentation in the periplasm of E.coli in a native state |
| Summary | Current Status of Technology:
1. Protein expressed in shake flask and 10L bioreactor.
2. Achieved yield of 250 mg/L (post-capturing purification step)
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| Advantages | 1. developed the process for the synthesis of the branched PEG reagent for PEGylation of Certolizumab to obtain Certolizumab pegol, at gram scale with activity and purity > 95%
2. Preparation of PEGylation reagent in around 10 g scale with yield of over 85%, purity of over 95% and activity of over 95%.
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Knowhow is listed under following categories
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Knowhow from
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| Scientific/ engineering subject areas |
Life sciences/ biosciences & engineering |
| Investor interest categories |
Biotechnology/ Biomedical/ Health Technologies |
| Industries |
Pharmaceuticals, Bulk Drugs, Formulations |
| Customer categories and nature of business |
Businesses and other industries (B2B) |
| Technology readiness levels
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Related documents:
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(Local uploaded copy)
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Database reference
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| Database record number |
20220309071906 |
| Date of upload |
10 / Mar / 2022 |
| Date of update |
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| URL to site when communicating about this knowhow |
http://techex.in/khdb/viewrecord.php?recordno=20220309071906 |
| Request for this technology |
Click here for Request Form |
